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Using 3-D Cell Culture Systems for Extracellular Vesicle Research

3-D cell culture recapitulates in vivo environments for generating physiologically relevant extracellular vesicles.

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Extracellular vesicles (EVs) are cell-to-cell communication vehicles and mediators of numerous physiological and pathological mechanisms. Because EVs reach their intended targets with greater specificity than many existing pharmaceuticals, researchers are interested in their potential as therapeutic delivery vectors. However, consistently producing clinical-grade EVs in high quantities requires that EV production takes place in physiologically-relevant environments. 3-D production systems such as hollow fiber bioreactors (HFBRs) offers scientists the ability to generate high-quality EVs for research and therapeutic applications.

Download this application note from FiberCell Systems to learn about HFBRs, how to use them to produce EVs, and the throughputs and quality that they help achieve.