Understanding Transplant Rejection with Single-Cell Proteomics

Researchers find key drivers of allograft rejection

A complicated immune response mediates transplanted organ and tissue rejection. To understand the role of different immune cells in this process, researchers use a new technology that performs highly multiplexed proteomics on single cells. By simultaneously analyzing multiple cytokines in a heterogeneous cell population, scientists identify key factors that drive transplant rejection by a subset of polyfunctional T cells with unique cytokine signatures.

Download this research summary from IsoPlexis to learn how researchers analyze heterogeneous immune cell populations with highly multiplexed functional proteomics.