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Understanding the Complexity of Cancer with Cryo-EM

Explore how researchers use cryogenic electron microscopy (cryo-EM) to identify how mutations affect protein signaling and function through structural or conformational changes.



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Cryogenic electron microscopy (cryo-EM) lets researchers observe biomolecules in their natural condition and capture complete, fully functional macromolecular complexes in different functional states. Structural biologists use cryo-EM to characterize how genetic mutations affect protein structures and conformations and identify how these alterations impact signaling and function in cancer. This information is important for understanding drivers of oncogenic signaling and factors affecting drug efficacy.

Download this ebook from The Scientist’s Creative Services Team and Thermo Fisher Scientific to learn about

  • Finding cancer drivers with cryo-EM
  • Using cryo-EM to characterize large protein complexes
  • How cryo-EM advances membrane receptor research
  • Landmarks in cancer research powered by cryo-EM