A More Sensitive Way to Determine Protein Structure

Verifying protein structure is essential to ensure a manufactured protein’s efficacy and safety, as minor conformational changes can affect function and stability. For example, researchers developing biosimilar molecules, which mimic existing therapeutic proteins, have to confirm similarity between both proteins. Microfluidic modulation spectroscopy (MMS) combines microfluidics with a high-powered infrared laser, allowing researchers to detect minimal conformational changes in complex samples.

Download this application note from RedShiftBio to discover how MMS can be integrated into the manufacturing process to determine the similarity and stability of a protein sample.