Toxic protein accumulation is a key hallmark of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Understanding protein aggregate formation, clearance, and spread in the brain is imperative to accurately diagnose diseases and fuel drug discovery. However, little is known about the structure of these aggregates as they are too complex to decipher using traditional structural biology methodologies.
Download this ebook from Thermo Fisher Scientific and The Scientist to learn how advancements in cryogenic electron microscopy (cryo-EM) allow researchers to determine protein aggregate atomic structures, transforming neurodegeneration research.
