Sixty years of culturing individual cell types on 2-D glass or plastic surfaces have shown it to be a powerful technique for studying cellular functions. However, cells do not grow on plastic in nature, are only exposed to serum in an activated state, and cell-matrix and cell-to-cell interactions not found in flasks play a key role in generating the 3-D biological organization we call multicellular "life."
Hollow fiber bioreactors (HFBR) can recreate the in vivo circulatory system geometry and culture cells in a 3-D, physiologically relevant manner. They have been used to recreate many tissue/cell specific structures in a manner that allows data to be collected in meaningful ways.
Download this white paper from FiberCell Systems to learn about how HFBRs are used in:
- Single cell-type and multi cell-type assays
- Antiviral and anticancer drug evaluations
- 3-D cellular models (blood vessels, blood-brain barrier)