--- title: "pIC50: The Advantages of Thinking Logarithmically" image: https://offers.the-scientist.com/hubfs/CDD_1800x640-2.png --- # [The Scientist](http://www.the-scientist.com/)   ## **pIC50: THE ADVANTAGES OF THINKING LOGARITHMICALLY** ![](https://offers.the-scientist.com/hs-fs/hubfs/The%20Scientist%20Scripts%20and%20Images/TS%20E-blast%20Images/BD_line-horz.jpg?width=600&name=BD_line-horz.jpg) ![CDD\_500x250](https://offers.the-scientist.com/hs-fs/hubfs/downloads/TS/CDD/Webinars/CDD_500x250.png?width=500&name=CDD_500x250.png) pIC50 is the negative log of the IC50 value when converted to molar. Since the nature of potency values is logarithmic, how the data is reported should also be log based. A decrease in potency from micromolar to nanomolar levels is an exponential change, not the linear change that an IC50 graph would depict. pIC50 is really the right way to think about potency of compounds, and using this value encourages the logarithmic thinking that is required for dealing with concentration-dependent relationships.    **Watch this webinar from *Collaborative Drug Discovery* to learn about:** - The fallacy of using non-logarithmic equations when discussing potency values - How using pIC50 helps you get a better sense of the relative potencies, calculate the correct mean of multiple values, and select better sampling doses *All product names, logos, and brands are the property of their respective owners. All company, product, and service names used on this website are for identification purposes only.*   [![Share on Facebook](https://static.hubspot.com/final/img/common/icons/social/facebook-24x24.png)](http://www.facebook.com/share.php?u=https%3A%2F%2Foffers.the-scientist.com%2Fpic50-the-advantages-of-thinking-logarithmically-cdd%3Futm_medium%3Dsocial%26utm_source%3Dfacebook) [![Share on LinkedIn](https://static.hubspot.com/final/img/common/icons/social/linkedin-24x24.png)](http://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Foffers.the-scientist.com%2Fpic50-the-advantages-of-thinking-logarithmically-cdd%3Futm_medium%3Dsocial%26utm_source%3Dlinkedin) [![Share on Twitter](https://static.hubspot.com/final/img/common/icons/social/twitter-24x24.png)](https://twitter.com/intent/tweet?original_referer=https%3A%2F%2Foffers.the-scientist.com%2Fpic50-the-advantages-of-thinking-logarithmically-cdd%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&url=https%3A%2F%2Foffers.the-scientist.com%2Fpic50-the-advantages-of-thinking-logarithmically-cdd%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&source=tweetbutton&text=pIC50%3A%20The%20Advantages%20of%20Thinking%20Logarithmically) [![Share on Email](https://static.hubspot.com/final/img/common/icons/social/email-24x24.png)](mailto:?subject=Check%20out%20https%3A%2F%2Foffers.the-scientist.com%2Fpic50-the-advantages-of-thinking-logarithmically-cdd%3Futm_medium%3Dsocial%26utm_source%3Demail%20&body=Check%20out%20https%3A%2F%2Foffers.the-scientist.com%2Fpic50-the-advantages-of-thinking-logarithmically-cdd%3Futm_medium%3Dsocial%26utm_source%3Demail) *The Scientist*needs the contact information you provide us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our [Privacy Policy](https://www.the-scientist.com/privacy-policy).   [![](https://offers.the-scientist.com/hs-fs/hubfs/Images/TS/The%20Scientist%20Logo_white%20on%20222222.png?width=250&name=The%20Scientist%20Logo_white%20on%20222222.png)](https://www.the-scientist.com) The Scientist c/o LabX Media Group 1000 N West Street, Suite 1200, Wilmington, Delaware, United States,19801 Toll Free: 888.788.0328 | Phone: 705.528.6888 Email: [privacy@the-scientist.com](mailto:privacy@the-scientist.com) © 1986-2026[The Scientist](http://the-scientist.com/)[Privacy Policy](https://www.the-scientist.com/privacy-policy)