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p53 as an Immune System Modulator in Cancer

Best known as a cell cycle regulator, p53 signaling mediates pro and anti-cancer immune responses as well

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p53 is best known as a cell cycle regulator and an initiator of apoptosis and senescence. p53 dysfunction often leads to cancer; however, the relationship between p53 and oncogenesis goes beyond cell cycle dysregulation. In homeostatic conditions, p53 is a prominent immune regulator, from facilitating effector cell recognition to stimulating paracrine activity. As such, p53 mutations not only unshackle cancer cell proliferation, but also aid tumorigenesis, growth, and metastasis by impacting immune function in deleterious ways. Characterizing this immune function is essential in order to identify the unique superhero and supervillain cell subsets. IsoPlexis’ platform is able to identify these rare cell subsets which correlate to anti-tumor response or those contributing to disease progression, enabling and accelerating the development of curative medicines.

Download this poster from IsoPlexis to learn more about the p53-mediated pathways that impact immune system responses to cancer.