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WHITE PAPER

Optimizing Translational IBD Capabilities

How to Select the Right Preclinical Mouse Model

 

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Inflammatory bowel disease (IBD) arises from complex interactions between genes, the immune system, the microbiome, and environmental triggers. Further research must be done because a significant proportion of IBD patients do not respond to current treatments. There is an increasing array of mouse IBD models with their own advantages and disadvantages. One model alone will not fully replicate human IBD; therefore, researchers must consider the pros and cons of each model in relation to the mechanism of action they are investigating.

Download this white paper from CrownBio to learn

  • The strengths and limitations of the five major IBD mouse models
  • The relevance of each mouse model to human IBD mechanisms
  • How to improve the translational relevance of IBD mouse models