Comprehensive tumor profiling using next generation sequencing (NGS) technologies is key to discovering new, targetable biomarkers for cancer research. However, converting tumor samples into NGS libraries can be challenging. Tumor samples may be formalin-fixed and paraffin-embedded (FFPE) to preserve tissue structure, which reduces tumor DNA quality. Similarly, cell-free DNA (cfDNA) samples collected from liquid biopsies often yield low quantities of tumor-derived DNA. Careful library conversion of low-quality, low-quantity DNA samples is critical to sequencing success.
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