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Increasing Chromatography Sensitivity with Ultrapure Water

HPLC-grade water does not adequately separate trace compounds in chromatography experiments.



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In chromatography applications, impurities in the water comprising mobile phase solvents and samples affect the sensitivity and reproducibility of experimental results. Researchers quantifying trace compounds require chromatography-grade, ultrapure water to minimize baseline noise and improve signal-to-noise ratios. However, HPLC-grade water stored in bottles accumulates impurities over time. To avoid this problem, researchers should make their own ultrapure water fresh in the laboratory.

Download this application note from Sartorius to learn

  • How to obtain fresh, ultrapure water using the Arium® Mini Plus system
  • How ultrapure water surpasses bottled LC-MS grade water in trace analysis