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Immune Cell Activity Mediates Severe COVID-19 Pathogenesis

Profiling of immune cells uncovers mechanisms underlying lung inflammation.

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COVID-19 manifests in a variety of ways, and while many patients develop a self-limiting disease and recover, a considerable proportion suffer severe lung disease that can progress to acute respiratory distress syndrome (ARDS). The immune response is involved in both situations, acting in either a coordinated fashion to clear infection and establish virus-specific immunity, or advancing harmful cytokine storms. It is therefore very important to identify the specific immune mechanisms responsible for provoking a pathogenic immune response—as opposed to a disease-clearing one—to SARS-CoV-2.

Download this research summary from IsoPlexis to learn how researchers used immune cell functional profiling to find evidence for myeloid cell-driven lung inflammation in severe COVID-19 and reveal potential therapeutic targets.