Today, cultured mammalian cells are the predominant platform for recombinant protein production for clinical applications owing to their potential for superior quality, bioactivity, and efficacy. However, mammalian cell-based production of recombinant proteins and conditioned medium in the typical research laboratory can be cumbersome. Large amounts of equipment is typically required, scaling-up can be costly, and most importantly, classical batch-style 2-D cultures are not very biologically relevant systems.
Hollow fiber bioreactors (HFBR) provide a more physiologic, in vivo-like 3-D environment than other cell culture methods, and can also result in improved protein folding and more uniform post-translation modifications over time. Protein yields are higher and more concentrated, with small volumes facilitating down-stream purification.
Download this white paper from FiberCell Systems to learn more about the advantages of HFBRs.