A Hollow Fiber Bioreactor Allows Any Lab to Efficiently Express Recombinant Proteins in Mammalian Cells

John J.S. Cadwell


Today, cultured mammalian cells are the predominant platform for recombinant protein production for clinical applications owing to their potential for superior quality, bioactivity, and efficacy. However, mammalian cell-based production of recombinant proteins and conditioned medium in the typical research laboratory can be cumbersome. Large amounts of equipment is typically required, scaling-up can be costly, and most importantly, classical batch-style 2-D cultures are not very biologically relevant systems.
Hollow fiber bioreactors (HFBR) provide a more physiologic, in vivo-like 3-D environment than other cell culture methods, and can also result in improved protein folding and more uniform post-translation modifications over time. Protein yields are higher and more concentrated, with small volumes facilitating down-stream purification.
Download this white paper from FiberCell Systems to learn more about the advantages of HFBRs.