RESEARCH SNAPSHOT
Exploring Neurodegeneration with Immune Profiling
Researchers study the immune system using flow cytometry and single-cell sequencing.
The adaptive immune system can have beneficial and detrimental effects on the central nervous system (CNS), causing mild cognitive impairment and neurodegenerative diseases, such as Alzheimer's disease. Immune profiling provides valuable insights into underlying disease mechanisms and the impact of unique immune cell signatures in neurodegeneration. Researchers use single cell immune profiling to investigate gene expression and immune repertoire changes in the CNS, including antigen-specific clonal expansion of CD8+ T cells.
Download this research snapshot from 10x Genomics to learn how researchers used Chromium Single Cell Immune Profiling to analyze
- Gene expression
- Surface protein expression
- Antigen specificity
- T cell receptor sequences
