Functional genetic screens are a powerful tool for establishing links between genotypes and phenotypes. They are particularly relevant for identifying potential genetic factors underpinning disease onset or progression. Over the past decade, technological and methodological breakthroughs have advanced screening processes. In particular, the emergence of CRISPR allows researchers to modulate gene expression in a controlled, robust, and highly specific manner.
Download this ebook from Synthego to learn how researchers use CRISPR-mediated loss-of-function screens to identify and validate gene targets for drug discovery.