CORRELATION BETWEEN MUTATIONS FOUND IN FFPE TUMOR TISSUE AND PAIRED cfDNA SAMPLES
Tumor tissue is typically removed and stored as formalin-fixed, paraffin-embedded (FFPE) tissue, a process that preserves the morphological structures well but chemically modifies and degrades the nucleic acids. Liquid biopsies represent an alternative to this, as the cell-free DNA (cfDNA) present in the blood includes DNA derived from cancer cells, facilitating the detection of cancer biomarkers.
Download this poster from Beckman Coulter to learn about:
How to extract DNA from FFPE and liquid biopsy samples
The respective mutational profiles found in matched FFPE and plasma samples
Where mutational mismatchs were found in the chromosome
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