Genetically engineered mice are invaluable tools for the in vivo study of gene function. The use of gene modification methods in both the embryo and embryonic stem cells has provided valuable insights into human disease and is a crucial platform for drug target discovery and validation.
The CRISPR/Cas gene editing system has recently emerged as a versatile technology for inducing precise genetic alterations in different species. Given the importance of genetically engineered mice in modeling human disease, the power of the CRISPR/Cas system has been used to revolutionize the field of custom mouse model generation and facilitate biomedical research.
With this application note from Taconic, learn about:
- The utility of gene editing vs. other methods of gene manipulation
- How CRISPR/Cas-based gene editing methods work
- The advantages and limitations of in-embryo gene editing technologies
- Model types generated using CRISPR/Cas9
- The "typical" CRISPR project, from start to finish