Functional proteomic adaptations leading to increased metastasis
Tumor growth accompanied by increased migratory capabilities leads to cancer cell extravasation and metastasis. The underlying mechanisms for these phenotypic changes is unclear, but Denis Wirtz at Johns Hopkins University believes that cytokines play a key role. Using IsoPlexis’ functional proteomics, Wirtz and his team investigated the role of cell density on cancer cell secretory behavior and how these functional proteomic adaptations led to an increase in cell migration.
Download this research summary to find out how analyzing the secretome revealed a new mechanism for cell density-mediated metastasis.
