--- title: A multi-omics approach to overcome solid tumor drug resistance image: https://offers.the-scientist.com/hubfs/downloads/TS/TS_Isoplexis_2020/TS_Isoplexis_July%20Research%20Summary/TS_isoplexis_July%20Research%20Summary_New%20Images/Isoplexis_Banners-V2-1800x640.png --- ![The Scientist Logo\_white](https://offers.the-scientist.com/hs-fs/hubfs/The%20Scientist%20Logo_white.png?width=702&name=The%20Scientist%20Logo_white.png "The Scientist Logo_white") RESEARCH SUMMARY # A Multi-Omics Approach to Overcome Solid Tumor Drug Resistance ## Single-cell proteomics and metabolomics methods unlock drug resistance mechanisms ![IsoPlexis Logo\_2020 New - Color and White](https://offers.the-scientist.com/hubfs/downloads/TS/TS_Isoplexis_2020/IsoPlexis%20Logo_2020%20New%20-%20Color%20and%20White.bmp)   ![Isoplexis\_Banners-V2-473x360](https://offers.the-scientist.com/hs-fs/hubfs/downloads/TS/TS_Isoplexis_2020/TS_Isoplexis_July%20Research%20Summary/TS_isoplexis_July%20Research%20Summary_New%20Images/Isoplexis_Banners-V2-473x360.png?width=473&name=Isoplexis_Banners-V2-473x360.png "Isoplexis_Banners-V2-473x360") Cancer cells constantly evolve in response to acute and chronic stimuli. Drug resistance is one product of this evolution, as cells quickly adopt drug-resistant states when exposed to pharmacological treatments. How cancer cells reach drug resistance remains unclear, so researchers from the California Institute of Technology implemented a multi-omics approach for characterizing drug resistance mechanisms using IsoPlexis’ single-cell proteomics. **Download this research summary to find out how James Heath's team used predictive single-cell functional proteomic and metabolic assays to investigate changing cellular states in melanoma cells for the development of improved targeted therapies.** [![Share on Facebook](https://offers.the-scientist.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/FB.png?width=24&name=FB.png)](http://www.facebook.com/share.php?u=https%3A%2F%2Foffers.the-scientist.com%2Fa-multi-omics-approach-to-overcome-solid-tumor-drug-resistance-isoplexis-july-research-summary%3Futm_medium%3Dsocial%26utm_source%3Dfacebook) [![Share on LinkedIn](https://offers.the-scientist.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/linkedIn.png?width=24&name=linkedIn.png)](http://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Foffers.the-scientist.com%2Fa-multi-omics-approach-to-overcome-solid-tumor-drug-resistance-isoplexis-july-research-summary%3Futm_medium%3Dsocial%26utm_source%3Dlinkedin) [![Share on Twitter](https://offers.the-scientist.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/Twitter.png?width=24&name=Twitter.png)](https://twitter.com/intent/tweet?original_referer=https%3A%2F%2Foffers.the-scientist.com%2Fa-multi-omics-approach-to-overcome-solid-tumor-drug-resistance-isoplexis-july-research-summary%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&url=https%3A%2F%2Foffers.the-scientist.com%2Fa-multi-omics-approach-to-overcome-solid-tumor-drug-resistance-isoplexis-july-research-summary%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&source=tweetbutton&text=A%20multi-omics%20approach%20to%20overcome%20solid%20tumor%20drug%20resistance) [![Share on Email](https://offers.the-scientist.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/email.png?width=24&name=email.png)](mailto:?subject=Check%20out%20https%3A%2F%2Foffers.the-scientist.com%2Fa-multi-omics-approach-to-overcome-solid-tumor-drug-resistance-isoplexis-july-research-summary%3Futm_medium%3Dsocial%26utm_source%3Demail%20&body=Check%20out%20https%3A%2F%2Foffers.the-scientist.com%2Fa-multi-omics-approach-to-overcome-solid-tumor-drug-resistance-isoplexis-july-research-summary%3Futm_medium%3Dsocial%26utm_source%3Demail) The Scientist c/o LabX Media Group 1000 N West Street, Suite 1200, Wilmington, Delaware, United States, 19801 Toll Free: 888.788.0328 | Phone: 705.528.6888 Email: [privacy@the-scientist.com](mailto:privacy@the-scientist.com) [Privacy Policy](https://www.the-scientist.com/privacy-policy) © 1986-2022 [The Scientist](http://the-scientist.com/)   [![The Scientist Logo\_white](https://offers.the-scientist.com/hs-fs/hubfs/The%20Scientist%20Logo_white.png?width=702&name=The%20Scientist%20Logo_white.png "The Scientist Logo_white")](https://www.the-scientist.com) The Scientist needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our [Privacy Policy.](https://www.the-scientist.com/privacy-policy)