A Multi-Omics Approach to Overcome Solid Tumor Drug Resistance

Cancer cells constantly evolve in response to acute and chronic stimuli. Drug resistance is one product of this evolution, as cells quickly adopt drug-resistant states when exposed to pharmacological treatments. How cancer cells reach drug resistance remains unclear, so researchers from the California Institute of Technology implemented a multi-omics approach for characterizing drug resistance mechanisms using IsoPlexis’ single-cell proteomics.

Download this research summary to find out how James Heath's team used predictive single-cell functional proteomic and metabolic assays to investigate changing cellular states in melanoma cells for the development of improved targeted therapies.