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A Guide for Optimizing Arrayed CRISPR Screens

Using sgRNA libraries for target identification and validation during drug discovery


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Loss-of-function (LOF) screens measure the phenotypic effects of gene disruptions, which helps researchers identify and validate gene targets for drug discovery. CRISPR-Cas9 technology has enabled great advances in LOF screening. While researchers typically use pooled CRISPR screens to assess fitness phenotypes, arrayed screens are amenable to a variety of functional assays.

Download this ebook from Synthego to learn more about using arrayed CRISPR screens for target identification and drug discovery validation.