A Hollow Fiber Bioreactor Allows Any Lab to Efficiently Express Recombinant Proteins in Mammalian Cells

John J.S. Cadwell

 

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Today, cultured mammalian cells are the predominant platform for recombinant protein production for clinical applications owing to their potential for superior quality, bioactivity, and efficacy. However, mammalian cell-based production of recombinant proteins and conditioned medium in the typical research laboratory can be cumbersome. Large amounts of equipment is typically required, scaling-up can be costly, and most importantly, classical batch-style 2-D cultures are not very biologically relevant systems.
 
Hollow fiber bioreactors (HFBR) provide a more physiologic, in vivo-like 3-D environment than other cell culture methods, and can also result in improved protein folding and more uniform post-translation modifications over time. Protein yields are higher and more concentrated, with small volumes facilitating down-stream purification.
 
Download this white paper from FiberCell Systems to learn more about the advantages of HFBRs.