Immunotherapy harnesses the components of an individual's own immune system to identify and attack cancer cells. One form of immunotherapy is adoptive cell transfer (ACT), where the patient's immune cells are collected, genetically modified, and re-infused.
CAR-T immunotherapy is one type of ACT that has shown exceptional promise against both blood cancers and solid tumors. CAR-T cells are T cells expressing specialized engineered receptors called chimeric antigen receptors (CARs) which counter tumor evasion by improving recognition specificity for tumor cells and removing the need for MHC co-stimulation.
Download this original eBook from The Scientist to learn more about:
- T-cell receptor-mediated cancer cell killing
- Constructing CAR-T cells
- Producing CAR-T cells
- Manufacturing CAR-T cells for the clinic
