Physiologically relevant models were, in recent history, thought of as the holy grail in life science research. However, with three-dimensional (3-D) cell culture models now better able to mimic in vivo conditions, living organism replicas are within sight.
The ability of 3-D cultures to mimic the microenvironment of in vivo tissues sets the technique apart. Compared to 2-D cultures, cellular models containing three-dimensions better represent intricate cell-cell interactions, more closely resemble the exquisite nature of cellular communication, and have matrices that are analogous to in vivo structures.
Download this eBook from The Scientist to learn about:
  • How the third dimension affects cell behavior
  • The similarities and differences between 2-D and 3-D culture
  • Common 3-D culture models
  • Imaging and analyzing 3-D culture models
This eBook was made possible by an educational grant from PerkinElmer.